Biliary Atresia: GGT vs Histopathology as Diagnostic Tool
نویسندگان
چکیده
Background: Biliary Atresia (BA) also known as "progressive obliterative cholangiopathy" is one of the most common conditions requiring pediatric liver transplant and surgically treatable cause neonatal cholestasis. Associated malformations are present in 25% cases it East Asia, with incidence reported high 5,000. BA presents cholestatic Jaundice, initially indistinguishable from physiological jaundice. Symptoms include progressive cholestasis, causing yellowing skin, pruritis, pale stools, dark urine.
 Methods: This study a Cross sectional conducted at Department Pediatric Medicine, The Children’s Hospital & Institute Child’s Health, Lahore duration 6 months (2018-2019), after approval Institution’s Review Board. All patients age ≤ 14 months, presenting emergency jaundice fulfilling inclusion criteria were included this study.
 Results: In our total 150 enrolled. mean was 7.13 ± 3.81. male to female ratio 1.3:1, 86(57.33%) males 64(42.67%) females. results showed that initial observation 8.54 3.89 days minimum maximum 2 15 days, respectively. GGT level 303.13 58.53. study, on basis diagnosed positive 83 negative 67 cases, which exceptionally consistent gold standard i.e. histopathology 82 for labelled 68 negative.
 Conclusion: Serum elevated levels suggestive biliary atresia.
منابع مشابه
[Extrahepatic biliary atresia: diagnostic methods].
OBJECTIVE To emphasize the importance of precocious diagnosis of extrahepatic biliary atresia and its direct relationship with the surgical re-establishment of the biliary flow before the second month of life. To discuss several complementary methods with the aim of selecting the ones that present better evidence, and avoiding delays in diagnosis and worse prognostic. SOURCES OF DATA Bibliogr...
متن کاملNon-Invasive Diagnostic Methods for Differentiation of Biliary Atresia from Neonatal Hepatitis in Upper Egypt
Background Cholestatic jaundice in infancy is always pathologic and mainly caused by biliary atresia (BA), and neonatal hepatitis (NH). The early discrimination of both conditions is critical for the outcome of BA. We aimed to assess different non-invasive diagnostic tools in differentiating BA from NH. Materials and Methods Forty infants (25 boys, 15 girls) with cholestatic jaundice and final...
متن کاملBiliary atresia
Biliary atresia (BA) is a cholangiodestructive disease affecting biliary tract, which ultimately leads to cirrhosis, liver failure and death if not treated. The incidence is higher in Asian countries than in Europe. Up to 10% of cases have other congenital anomalies, such as polysplenia, asplenia, situs inversus, absence of inferior vena cava and pre-duodenal portal vein, for which we have coin...
متن کاملBiliary atresia.
Biliary atresia is a neonatal obstructive cholangiopathy characterized by a fibrosclerosing obliteration of the extrahepatic bile duct that uniquely presents in the first months of life (1). The condition occurs in approximately 1 in 8,000 to 1 in 15,000 live births and accounts for 30% of all cases of cholestasis in young infants. Biliary atresia is the most frequent cause of chronic end-stage...
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ژورنال
عنوان ژورنال: Journal of pharmaceutical research international
سال: 2022
ISSN: ['2456-9119']
DOI: https://doi.org/10.9734/jpri/2022/v34i32b36110